Diagnosis and Treatment of Sinusoidal obstruction syndrome (Veno-occlusive disease) after Haematopoietic cell transplantation

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Hepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation.

Hepatic veno-occlusive disease (VOD), increasingly referred to as sinusoidal obstruction syndrome, is a well-recognized complication of hematopoietic stem cell transplantation and contributes to considerable morbidity and mortality. In the Western Hemisphere, VOD, classified as a conditioning-related toxicity, is most commonly caused by stem cell transplantation. VOD has been described after al...

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Can recombinant thrombomodulin play a preventive role for veno-occlusive disease after haematopoietic stem cell transplantation?

Dear Sirs, Although haematopoietic stem cell transplantation (HSCT) is being used for haematopoietic reconstitution following highdose chemotherapy for malignancy, it involves some serious transplant-related complications (1, 2), such as graft-versushost disease (GVHD) and vascular disorders (such as veno-occlusive disease (VOD), pulmonary vasculopathy, thrombotic microangiopathy (TMA), and cap...

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Fulminant liver failure due to severe veno-occlusive disease after haematopoietic cell transplantation: a depressing experience.

BACKGROUND Between 1988 and 2002, eight patients were referred to our unit from other institutions, for management of fulminant hepatic failure (FHF) complicating severe veno-occlusive disease (VOD). AIM To review our experience with these patients. METHODS Retrospective analysis of medical case notes. RESULTS In 7/8 cases, a histological diagnosis of VOD was confirmed by transjugular liv...

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Manifestations and management of veno-occlusive disease/sinusoidal obstruction syndrome in the era of contemporary therapies.

The concept of veno-occlusive disease (VOD), along with our understanding of it, has historically been and remains an evolving phenomenon. This review presents a broad view of VOD, also known as sinusoidal obstruction syndrome (SOS), including (1) traditional hematopoietic stem cell transplant-associated VOD/SOS, (2) late-onset VOD/SOS, (3) pulmonary VOD, and (4) VOD/SOS associated with chemoth...

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Biomarkers for hepatic sinusoidal obstruction syndrome after hematopoietic cell transplantation

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Hepatic sinusoidal obstruction syndrome (SOS), previously known as veno-occlusive disease, is one of the major complications during the early period after hematopoietic cell transplantation (HCT). The disease is caused by toxic injury of conditioning therapy...

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ژورنال

عنوان ژورنال: Journal of Hematopoietic Cell Transplantation

سال: 2016

ISSN: 2186-5612

DOI: 10.7889/hct.5.124